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The FUS protein participates in circRNA biogenesis

GSE83226 Mus musculus Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing 6 samples Submitted 2017/02/27 Platform GPL17021
Summary
The RNA binding protein FUS exerts its function in several RNA biosynthetic processes; moreover, mutations leading to changes in its expression levels or alterations in cellular compartmentalization have been linked to the pathogenesis of Amyotrophic Lateral Sclerosis. Here, we describe an additional novel function of FUS, that is the control of back-splicing reactions which lead to circular RNA (circRNA) production. We identified circRNAs expressed in murine ES-derived motoneurons and then compared their levels in control versus FUS-/- cells. We discovered that a considerable number of circRNAs is affected by FUS levels.
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Also filed as BioProject PRJNA325303 and SRA study SRP076387. Searching any of these in the dataset finder brings you back here.

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