The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-RNA Seq-Resistant, sensitive and healthy control
RNA-seq (gene expression) · human · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE87187_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA343815 and SRA study SRP090251. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM2324260 NB4 Sample 1 RNA Seq-1
- GSM2324261 TF-1 Sample 2 RNA Seq-1
- GSM2324262 HEL Sample 3 RNA Seq-1
- GSM2324263 MA9.3RAS Sample 4 RNA Seq-1
- GSM2324264 K562 Sample 5 RNA Seq-1
- GSM2324265 ML-2 Sample 6 RNA Seq-1
- GSM2324266 NOMO-1 Sample 7 RNA Seq-1
- GSM2324267 U937 Sample 8 RNA Seq-1
- GSM2324268 MA9.3ITD Sample 9 RNA Seq-1
- GSM2324269 CD34+ HSPC-#1 Sample 10 RNA Seq-1
- GSM2324270 MNC-#1 Sample 11 RNA Seq-1
- GSM2324271 CD34+ HSPC-#2 Sample 12 RNA Seq-1
- GSM2324272 MNC-#2 Sample 13 RNA Seq-1
- GSE87189 The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-RNA Seq-PBS / R-2HG treatment 12 samples shares r-2hg, anti-leukemic, modifier-rna, depends
- GSE87190 The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-M6A Seq 20 samples shares r-2hg, anti-leukemic, depends
- GSE319868 A novel potent and selective GCN2 inhibitor, APL-4098, has anti-leukemic activity through dysregulation of mitochondrial function 64 samples shares anti-leukemic
- GSE324546 Anti-leukemic effect of MAR-3.6.2, a novel RAN inhibitor, on AML-LSCs by targeting RAN. 18 samples shares anti-leukemic
- GSE282364 Anti-leukemic effect of TGN-1062, a novel CDK7 inhibitor, on AML-leukemic stem cells by targeting RNA modification and Mitochondrial metabolism 12 samples shares anti-leukemic
- GSE318493 Sialylated CD43 forms a glyco-immune barrier that restrains anti-leukemic immunity 8 samples shares anti-leukemic
- GSE304766 An inhibitor of UHM splicing factors exerts anti-leukemic activity by altering cell cycle progression and reducing lysosome acidification 8 samples shares anti-leukemic
- GSE296195 Anti-Leukemic Effects of Velcrin in SLFN12-Expressing Acute Myeloid Leukemia 8 samples shares anti-leukemic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.