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The EMT-activator Zeb1 is crucial for cellular plasticity and drives metastasis in pancreatic cancer

GSE87472 Mus musculus Expression profiling by array 36 samples Submitted 2017/03/16 Platform GPL17543
Summary
Depletion of Zeb1 in a KPC-model for pancreatic cancer affected strongly the formation of precursor lesions, tumour grading, invasion and notably metastasis during PDAC progression. In this context, EMT is important for metastasis, but there is variability and specificity (and not redundancy) in the role and function of different EMT-inducing transcription factors.
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Also filed as BioProject PRJNA344877. Searching any of these in the dataset finder brings you back here.

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