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The EMT-activator Zeb1 is crucial for cellular plasticity and drives metastasis in pancreatic cancer

GSE87472 Mus musculus (mouse) Expression microarray 36 samples Submitted 2017/03/16 Platform GPL17543
At a glance

Expression microarray · mouse · 36 samples

What it is
Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism
Mus musculus (mouse)
Samples
36 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed expression table (series matrix) and the array files, from NCBI.
Summary (written by the submitters)
Depletion of Zeb1 in a KPC-model for pancreatic cancer affected strongly the formation of precursor lesions, tumour grading, invasion and notably metastasis during PDAC progression. In this context, EMT is important for metastasis, but there is variability and specificity (and not redundancy) in the role and function of different EMT-inducing transcription factors.
This dataset
Open GSE87472 in finder → Find more mouse microarray datasets →
Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗
3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE87472_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA344877. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 28414315) ↗
Study design
15 conditions, mostly in duplicate
KPCZ_E_426 ×3 KPCZ_E_346 ×3 KPC_E_661 ×3 KPC_M_827 ×2 KPC_M_550 ×2 KPCZ_E_398 ×2 KPCZ_E_387 ×2 KPCZ_E_340 ×2 +10 more

Supports a between-group comparison across 33 samples.

How we read this: 15 replicated groups read from 36 sample titles; they account for 33 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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