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Autophagy maintains metabolism and functional activity of a subset of aged hematopoietic stem cells [ERRBS]

GSE89338 Mus musculus Methylation profiling by high throughput sequencing 10 samples Submitted 2017/03/03 Platform GPL17021
Summary
Autophagy is critical for protecting HSCs from metabolic stress. Here, we used a genetic approach to inactivate autophagy in adult HSCs by deleting the Atg12 gene. We show that loss of autophagy causes accumulation of mitochondria and an oxidative phosphorylation (OXPHOS)-activated metabolic state, which drives accelerated myeloid differentiation likely through epigenetic deregulations rather than transcriptional changes, and impairs HSC self-renewal activity and regenerative potential.
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Also filed as BioProject PRJNA351841 and SRA study SRP092337. Searching any of these in the dataset finder brings you back here.

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