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Molecular analysis of endothelial and immune cells after anti-angiogenic cancer immunotherapy

GSE94920 Mus musculus Expression profiling by high throughput sequencing 63 samples Submitted 2017/04/26 Platform GPL17021
Summary
Organism: Mus musculus Experiment type: Gene expression profiling by high throughput sequencing Summary: Pathological angiogenesis is a hallmark of cancer and therapeutic target. Vascular-endothelial growth factor-A (VEGFA) and angiopoietin-2 (ANGPT2/ANG2) sustain tumor angiogenesis and limit anti-tumor immunity. We show that combined ANGPT2 and VEGFA blockade by mono-specific antibodies (LC06 + B20) or a bi-specific antibody (A2V) provides synergistic anti-tumoral benefits in both transgenic and transplant tumor models. We further show that that combination of agonistic anti-CD40 or blocking anti-PD1 antibodies with ANGPT2/VEGFA blockade improves therapeutic response and induces pleiotropic immune mechanisms that facilitate tumor control.
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Direct links to NCBI, no account and no request form: the whole study as GSE94920_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 63 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA374860 and SRA study SRP099843. Searching any of these in the dataset finder brings you back here.

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