GEO series

Mapping the Genetic Architecture of Gene Expression in Human Liver

GSE9588 Homo sapiens Expression profiling by array 427 samples Submitted 2008/05/08 Platform GPL4372

Summary

To uncover the genetic determinants affecting expression in a metabolically active tissue relevant to the study of obesity, diabetes, atherosclerosis, and other common human diseases, we profiled 427 human liver samples on a comprehensive gene expression microarray targeting greater than 40,000 transcripts and genotyped DNA from each of these samples at greater than 1,000,000 SNPs. The relatively large sample size of this study and the large number of SNPs genotyped provided the means to assess the relationship between genetic variants and gene expression and it provided this look for the first time in a non-blood derived, metabolically active tissue. A comprehensive analysis of the liver gene expression traits revealed that thousands of these traits are under the control of well defined genetic loci, with many of the genes having already been implicated in a number of human diseases. Clincal data was requested, but not provided by submitter. Keywords: eQTL

This dataset

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Direct links to NCBI, no account and no request form: the whole study as GSE9588_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 427 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA103427. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 18462017) ↗

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