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Parasitic helminths repress the canonical intestinal stem cell program

GSE97405 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2018/04/12 Platform GPL17021
Summary
The intestinal helminth parasite Heligmosomoides polygyrus initiates infection in mice by penetrating the duodenal mucosa, where it develops while surrounded by a multicellular granulomatous infiltrate before emerging into the intestinal lumen. We examined early H. polygyrus infection to assess the epithelial response to disruption of the mucosal barrier. Unexpectedly, intestinal stem cell markers, including Lgr5 and Olfm4, were completely lost in crypts overlying larvae-associated granulomas. We sought to identify the mechanism by which the H. polygyrus granuloma represses the activity of intestinal stem cells.
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Also filed as BioProject PRJNA381696 and SRA study SRP103069. Searching any of these in the dataset finder brings you back here.

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