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CDK4/6 inhibitor resistance in prostate cancer

GSE99675 Homo sapiens Expression profiling by high throughput sequencing 30 samples Submitted 2018/05/31 Platform GPL16791
Summary
CDK4/6 kinase inhibitors have shown great promise in clinical trials in various cancer types and have recently entered clinical trial for advanced prostate cancer. Although patients are expected to respond well to this class of drugs, development of resistance in some patients is anticipated. To pre-empt this and study how prostate cancer may evade CDK4/6 inhibition, new resistance models were generated from LNCaP and LAPC4 prostate cancer cells cells by prolonged culturing in presence of 0.5uM palbociclib. RNA sequencing data was integrated with phospho-proteomics to unravel the molecular underpinnings of acquired resistance to palbociclib and resultant broad CDK4/6 inhibitor resistance.
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Direct links to NCBI, no account and no request form: the whole study as GSE99675_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 30 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA389297 and SRA study SRP108624. Searching any of these in the dataset finder brings you back here.

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