Drug, across the briefings
Pazopanib across 13 cancers
Pazopanib appears in 13 of the briefings; its FDA label names 2 of those diseases.
| Disease | FDA label | Open Targets stage, on which gene | Trials | Active |
|---|---|---|---|---|
| Kidney cancer | label names disease | approved on KDR | 66 | 8 |
| Soft tissue sarcoma | label names disease | approved on PDGFRA, PDGFRB | 42 | 6 |
| Acute myeloid leukemia | approved on KIT | 2 | 0 | |
| Bladder cancer | approved on FGFR3 | 6 | 0 | |
| Gastric cancer | approved on KDR | 3 | 0 | |
| Gastrointestinal stromal tumour | approved on KIT, PDGFRA | 4 | 0 | |
| Glioblastoma | approved on PDGFRA | 6 | 1 | |
| Hepatocellular carcinoma | approved on KDR | 2 | 0 | |
| Lower-grade glioma | approved on PDGFRA | — | — | |
| Melanoma | approved on KIT | 7 | 0 | |
| Osteosarcoma | approved on KDR | 6 | 1 | |
| Small intestine cancer | approved on KIT, PDGFRA | — | — | |
| Testicular cancer | approved on KIT | 1 | 0 |
The label column is the briefing's openFDA stage: a label whose Indications and Usage names the disease. The Open Targets column is the furthest clinical stage recorded for the drug against any gene on that briefing's target list, in any indication. Trials are ClinicalTrials.gov interventional studies naming the drug and the disease, from the briefing's trials stage; a dash means the briefing did not search this drug in that disease (it searches the drugs Open Targets lists against its own genes), which is not the same as none. Salt forms, biosimilar suffixes and formulation words are merged by the same rule the briefings use.