Postdoctoral Researcher in Genomics and Genome Editing

Postdoctoral Researcher in Genomics and Genome Editing

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

Applications are invited for a Postdoctoral Researcher position to work with Professor James Davies and Professor Ronjon Chakraverty. This is an exciting opportunity to work on developing cutting-edge genome editing methods as part of the new MRC Centre of Research Excellence (CoRE) in Therapeutic Genomics. The main focus of the work is to develop a bespoke platform for using genome editing to treat rare disease.

You will be responsible for planning and carrying out laboratory research, generating high quality data and writing up findings for publication. You will also need to present data and ideas at regular meetings, and to report and communicate on a regular basis with the Group Head. Working both independently and as part of a team, it is essential that you are able to communicate effectively.

You will have a PhD (or submitted thesis) in Haematology, Genome Editing or a related discipline, together with relevant experience. Experience of conducting complex genome editing and single cell genomics experiments, as well as designing and carrying out experiments with murine models of transplantation will be essential. Experience of purification of cells from blood and bone marrow using flow cytometry and cell sorting is also required together with experience of advanced genome editing including cloning of CRISPR gRNAs for custom screens, base editing (including alternative specificity Cas enzymes) and prime editing. Experience of off-target assays such as CIRCLE-seq and GUIDE-seq and a strong publication record are desirable.

This position is available fixed term for 12 months, funded by the Medical Research Council. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. Closing date for this position is 12.00 noon on 5 October 2026.