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The dynamics of gene expression in vertebrate embryogenesis at single cell resolution

GSE113074 Xenopus tropicalis Expression profiling by high throughput sequencing 75 samples Submitted 2018/04/28 Platform GPL24884
Summary
Time series of single cell transcriptome measurements can reveal dynamic features of cell differentiation pathways. From measurements of whole frog embryos spanning zygotic genome activation through early organogenesis we derived a detailed catalog of cell states in vertebrate development and a map of differentiation across all lineages over time. The inferred map recapitulates most if not all developmental relationships, and associates new regulators and marker genes with each cell state. We find that many embryonic cell states appear earlier than previously appreciated. We also assess conflicting models of neural crest development. Incorporating a matched time series of zebrafish development from a companion paper, we reveal conserved and divergent features of vertebrate early developmental gene expression programs.
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Direct links to NCBI, no account and no request form: the whole study as GSE113074_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 75 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA449931 and SRA study SRP142544. Searching any of these in the dataset finder brings you back here.

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