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Molecular subtypes of DLBCL have distinct chromosomal aberrations

GSE11318 Homo sapiens Expression profiling by array; Genome variation profiling by genome tiling array 406 samples Submitted 2008/09/04 Platform GPL570Platform GPL6400
Summary
We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal B cell lymphoma (PMBL) can be distinguished. Combining gene expression profiling and aCGH, revealed copy number abnormalities that had strikingly different frequencies in the three molecular DLBCL subtypes. These data provide genetic evidence that the DLBCL subtypes are distinct diseases that utilize different oncogenic pathways. Keywords: clinical history design
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Also filed as BioProject PRJNA106631. Searching any of these in the dataset finder brings you back here.

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