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Role of BAP1 in pancreatic cancer (MoGene-2_0)

GSE120075 Mus musculus Expression profiling by array 6 samples Submitted 2020/04/14 Platform GPL16570
Summary
Transcriptional profile of murine Bap1 null pancreatic cancer cell lines We found that BAP1 (BRCA1 Associated Protein-1) shows loss of heterozygosity in over 25% of pancreatic cancer patients and functions as tumor suppressor. Conditional deletion of Bap1 in murine pancreas led to genomic instability, accumulation of DNA damage, and an inflammatory response that evolved to pancreatitis with full penetrance. Concomitant expression of oncogenic KrasG12D led to malignant transformation and development of invasive and metastatic pancreatic cancer. At the molecular level, BAP1 maintains the integrity of the exocrine pancreas by regulating genome stability and its loss confers sensitivity to radio- and platinum-based therapies
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Also filed as BioProject PRJNA491696. Searching any of these in the dataset finder brings you back here.

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