← BioTransfer GEO Dataset Finder
GEO series

Gene Expression Analysis in Peripheral Blood of Patients with Rheumatoid Arthritis

GSE12653 Homo sapiens Expression profiling by array 72 samples Submitted 2009/09/03 Platform GPL7220
Summary
Peripheral blood cells in patients with rheumatoid arthritis before/after IL-6 inhibition The obtained conclusions on the change of each gene expression level before and after MRA medication were as follows. (1) In the case of IL-6, the specific time profile that the expression level dropped at day 21 and increased to some extent at day 42 was observed in 2 of 18 subjects. In other subjects, quite small change or small increase after day 7 was observed. (2) In the case of IL-6R as well as in IL-6, the specific time profile that the expression level dropped at day 21 and increased to some extent at day 42 was observed in 1 of 18 subjects. In other subjects, slow and small increase was observed in 6 of 18. (3) The ratio of mRNA expression level of membrane and soluble type of IL-6R showed marginal difference after tocilizumab treatment, (4) The distinct change of expression level of cytochrome P450 mRNA after tocilizumab treatment was hardly observed in most patients.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE12653_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 72 samples.

Also filed as BioProject PRJNA113057. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 72 more — browse all 72 samples with per-sample file links →

Similar datasets

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.