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IKK in mesothelioma

GSE129984 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/04/05 Platform GPL21103
Summary
perform gene expression silencing for both IKKs in AE17, AB2 and KPM1 cells using lentiviral shRNA pools. After validating gene silencing, RNA was extracted from both parental (shC) and daughter cells (shChuk, shIkbkb) and was send for RNAsequencing in order to define possible target genes, up or down regulated upon gene expression manipulation with lentiviral shRNA. These cell lines (parental and daughter) were evaluated in vitro for the role of IKKs in cell proliferation, survival and clonogenicity and in vivo for their impact in MPM development upon intrapleural injection in mice
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Direct links to NCBI, no account and no request form: the whole study as GSE129984_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA533336 and SRA study SRP192892. Searching any of these in the dataset finder brings you back here.

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