GEO series
Trancriptome-wide mapping of TET2-regulated m5C sites in mouse embryonic stem cells (mESCs)
GSE138534
Mus musculus
Expression profiling by high throughput sequencing; Other
18 samples
2025/09/21
GPL13112GPL21626
Summary
We mapped the transcriptome-wide distribution of m5C sites, which are under the regulation TET2, using immunoprecipitation with specific anti-5mC antibodies followed by next-generation high-throughput sequencing in Tet2 KO mESCs in comparison to wild-type mESCs. Our data revealed that TET2-mediated m5C modifications primarily localize in 3’UTR of mRNA. Moreover, transcripts containing TET2-regulated m5C sites are stabilized with longer lifetime in Tet2 deficiency mESCs, indicated by the lifetime-seq.
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