GEO series
PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [ChIP-seq]
GSE154083
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
13 samples
2025/11/20
GPL16791
Summary
Here, we mapped the binding sites of PAXT/ZFC3H1, NEXT/ZCCHC8 and their shared MTR4 helicase subunit. Our data highlight a key interplay between cohesin-mediated long-range interactions in 3D and ncRNA regulation by MTR4 helicase and nuclear RNA exosome.
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