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RNA-seq profiles of DP thymocytes from control and Suv39h1/Suv39h2 double knockout mice

GSE156296 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/27 Platform GPL19057
Summary
H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes for healthy cellular function. Here we investigate the transcriptomic effects of heterochromatin loss in primary immune cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes which catalyse heterochromatic H3K9me3 deposition.
Published in
Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription
Keenan CR, Coughlan HD, Iannarella N et al. · Genome research 2024 · PMID 38719473 · doi:10.1101/gr.279119.124
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Also filed as BioProject PRJNA657287 and SRA study SRP277566. Searching any of these in the dataset finder brings you back here.

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