Blood transcriptomics for diagnosis, risk, and treatment monitoring in tuberculosis reveal the evolution and resolution of TB disease: Does one signature capture all?
RNA-seq (gene expression) · human · 760 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 760 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE157657_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA662344 and SRA study SRP281425. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 760 more — browse all 760 samples with per-sample file links →
- GSE287043 Unique Mycobacterium tuberculosis-specific blood immune signatures in sarcoidosis: implications for clinical diagnosis 542 samples shares tuberculosis, diagnosis, signature
- GSE279063 Identification of mRNAs as potential blood based biomarekrs for diagnosis and therapeutic monitoring of active tuberculosis 65 samples shares tuberculosis, monitoring, diagnosis
- GSE79362 A blood RNA signature for tuberculosis disease risk: a prospective cohort study 355 samples shares tuberculosis, signature
- GSE293840 Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) 168 samples shares diagnosis, signature
- GSE328391 Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts [bulk RNA-seq] 125 samples shares tuberculosis, signature
- GSE298762 NSAIDS-XDR-TB clinical trial: A randomized pilot study to estimate the potential efficacy and safety of using adjunctive ibuprofen for the treatment of pre-XDR and XDR tuberculosis 73 samples shares tuberculosis, treatment
- GSE326212 Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts 17 samples shares tuberculosis, signature
- GSE268524 A robust circulating microRNA signature for diagnosis and early detection in pancreatobiliary cancer 1403 samples shares diagnosis, signature
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.