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Transcriptome analysis of wild type and MafB knockout macrophages stimulated for 24 h with IL-4

GSE162886 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/03 Platform GPL24247
Summary
The functional polarity of macrophages driven by specific cues within local milieu can play a pivotal role in the pathogenesis of various human diseases. Identifying a key regulator to control macrophage polarization is of great importance in the therapeutic strategies for modulating macrophage function to improve clinical outcome. Here, we identify MafB as an essential transcription factor to induce M2 macrophage polarization. The myeloid-specific genetic ablation of Mafb in mice causes a severe defect in M2 macrophage polarization, ultimately leading to a deterioration of inflammatory diseases such as experimental sepsis or colitis.
Published in
Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer
Choi SP, Yang J, Park IB et al. · Translational research : the journal of laboratory and clinical medicine 2026 · PMID 41692233 · doi:10.1016/j.trsl.2026.02.006
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Also filed as BioProject PRJNA683638 and SRA study SRP297128. Searching any of these in the dataset finder brings you back here.

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