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Transcriptome Investigation of HFD-fed mice treated or not with Glycoursodeoxycholic Acid

GSE168822 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/09 Platform GPL24247
Summary
Recent studies reveal that bile acid metabolite composition and its metabolism are changed in metabolic disorders, such as obesity, type 2 diabetes and metabolic associated fatty liver disease (MAFLD), yet its role and the mechanism remain largely unknown. Hepatic whole transcriptome analysis identified glycoursodeoxycholic acid (GUDCA), glycine-conjugated bile acid produced from intestinal bacteria, differentially regulated 189 genes involved in biological processes including sterol, cholesterol and steroid biosynthesis, lipid metabolism, circadian rhythm and regulation, and the cellular component in cytosol, cytoplasm and endoplasmic reticulum, and molecular function including catalytic activity and platelet-derived growth factor binding.
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Direct links to NCBI, no account and no request form: the whole study as GSE168822_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA714095 and SRA study SRP310432. Searching any of these in the dataset finder brings you back here.

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