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The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer's disease-like pathology by perturbing oligodendrocyte survival and neuronal homeostasis

GSE173242 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/12/31 Platform GPL21103
Summary
Central in AD-related neuroinflammation is the proinflammatory interleukin-12 (IL-12)/IL-23 signaling pathway whose inhibition has been shown to attenuate pathology and cognitive defects in AD-like mice. In order to explore which cell types are involved in this neuroinflammatory cascade, we used single-nuclei RNA sequencing in AD-like APPPS1 mice lacking or harboring IL-12/IL-23 signaling.
Published in
Interleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis
Schneeberger S, Kim SJ, Geesdorf MN et al. · Nature aging 2025 · PMID 40082619 · doi:10.1038/s43587-025-00816-2
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Also filed as BioProject PRJNA724867 and SRA study SRP316186. Searching any of these in the dataset finder brings you back here.

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