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Non-coding RNA and mRNA expression profile in multi-drug resistance of colorectal cancer

GSE173606 Homo sapiens Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing 9 samples Submitted 2024/04/28 Platform GPL11154
Summary
Background: Non-coding RNAs have been proved to play an essential role in the development and progression of various cancers. However, the functions and mechanisms of non-coding RNA and mRNA in multi-drug resistance of colorectal cancer have not been fully elucidated.Methods: We performed RNA-sequencing to screen differentially expressed non-coding RNA and mRNA in CRC chemo-resistant and chemo-sensitive cell lines. Results: The results showed that 1779 mRNAs, 64 miRNAs, 11 circRNAs and 295 lncRNAs were common differentially expressed in two chemo-resistant cell lines.Conclusions:The results of the study may provide new theories and therapeutic targets for multi-drug resistance in colorectal cancer.
Published in
Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer
Yao F, Xiang X, Zhou C et al. · Frontiers in genetics 2021 · PMID 34603369 · doi:10.3389/fgene.2021.696948
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Also filed as BioProject PRJNA726252 and SRA study SRP317902. Searching any of these in the dataset finder brings you back here.

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