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Vascular mitohormesis couples Mfn2 with improved systemic metabolism and healthspan

GSE174547 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/17 Platform GPL17021
Summary
In this study, we hypothesized that mitochondrial dynamics in ECs orchestrates whole-body metabolic status. Here we report that genetic deficiency of endothelial Mfn2 (Mfn2iΔEC) in mice, originated a mitohormetic response that caused favorable vascular adaptations with regards to antioxidant defenses, mitochondrial fitness and lipid oxidation. As a result, Mfn2iΔEC mice exhibited improved metabolism, resistance to diet-induced obesity and delayed age-related decline. Our results reveal vascular mitohormesis as a novel operation mode influencing systemic energy metabolism and healthspan. These findings endorse the endothelium as a genuine metabolic organ and a potential target against metabolic and age-related deterioration.
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Also filed as BioProject PRJNA730519 and SRA study SRP320114. Searching any of these in the dataset finder brings you back here.

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