CXCL9 links skin inflammation and fibrosis via CXCR3-dependent upregulation of collagen 1a1 in fibroblasts
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 17 × Bleomycin vs 6 × PBSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in FibroblastsThe Journal of investigative dermatology · 2023
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE187002_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA777251 and SRA study SRP344228. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 2 replicated groups read from 24 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5665618 Bleomycin 1 Bleomycin
- GSM5665619 Bleomycin 2 Bleomycin
- GSM5665620 Bleomycin 3 Bleomycin
- GSM5665621 Bleomycin 4 Bleomycin
- GSM5665622 Bleomycin 5 Bleomycin
- GSM5665623 PBS 1 PBS
- GSM5665624 Bleomycin 6 Bleomycin
- GSM5665625 Bleomycin 7 Bleomycin
- GSM5665626 PBS 2 PBS
- GSM5665627 Bleomycin 8 Bleomycin
- GSM5665628 Bleomcyin 9
- GSM5665629 PBS 3 PBS
- GSM5665630 Bleomycin 10 Bleomycin
- GSM5665631 Bleomycin 11 Bleomycin
- GSM5665632 PBS 4 PBS
- GSM5665633 Bleomycin 12 Bleomycin
- GSM5665634 Bleomycin 13 Bleomycin
- GSM5665635 Bleomycin 14 Bleomycin
- GSM5665636 Bleomycin 15 Bleomycin
- GSM5665637 Bleomycin 16 Bleomycin
- GSM5665638 PBS 5 PBS
- GSM5665639 PBS 6 PBS
- GSM5665640 Bleomycin 17 Bleomycin
- GSM5665641 Bleomycin 18 Bleomycin
- GSE229916 Pericytes and perivascular fibroblasts contribute to central nervous system fibrosis in a region dependent manner 832 samples shares fibroblasts, fibrosis
- GSE284808 Bulk RNAseq of sorted fibroblasts from a mouse model of stretch-mediated skin expansion 22 samples shares fibroblasts, skin
- GSE266899 The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen hydroxyprolination and favoring immune infiltration. 18 samples shares fibroblasts, collagen
- GSE267256 Bulk RNA-seq analysis reveals the crucial role of Collagen triplex helix repeat containing-1 (Cthrc1) cardiac fibroblasts for ventricular remodeling after myocardial infarction 17 samples shares fibroblasts, collagen
- GSE273123 Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling (Bulk RNA-Seq) 16 samples shares fibroblasts, fibrosis
- GSE297255 Sandfly saliva reprogrammes skin fibroblasts to enhance arbovirus infection 11 samples shares fibroblasts, skin
- GSE298633 Clec3b⁺ fibroblasts are the primary effectors of portal fibrosis following activation via a KLF4/periostin axis 8 samples shares fibroblasts, fibrosis
- GSE207029 Blockade of avb8 integrin synergizes with checkpoint inhibition to enhance anti-tumor immunity through Cxcl9-dependent augmentation of CD8+ T cell cytotoxicity 12 samples shares cxcl9
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.