Bulk RNA-seq analysis reveals the crucial role of Collagen triplex helix repeat containing-1 (Cthrc1) cardiac fibroblasts for ventricular remodeling after myocardial infarction
Single-cell RNA-seq · mouse · 17 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Single-cell and spatial transcriptomic profiling of cardiac fibroblasts following myocardial infarctionScientific data · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267256_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1110758 and SRA study SRP507187. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 5 replicated groups read from 17 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8263031 Col1a1 GFP+ Cardiac Fibroblasts 3 days after MI Replicate 1 Col1a1 GFP+ Cardiac Fib…
- GSM8263032 Col1a1 GFP+ Cardiac Fibroblasts 3 days after MI Replicate 2 Col1a1 GFP+ Cardiac Fib…
- GSM8263033 Col1a1 GFP+ Cardiac Fibroblasts 3 days after MI Replicate 3 Col1a1 GFP+ Cardiac Fib…
- GSM8263034 Col1a1 GFP+ Cardiac Fibroblasts 3 days after MI Replicate 4 Col1a1 GFP+ Cardiac Fib…
- GSM8263035 Col1a1 GFP+ Cardiac Fibroblasts 1 days after MI Replicate 1 Col1a1 GFP+ Cardiac Fib…
- GSM8263036 Col1a1 GFP+ Cardiac Fibroblasts 1 days after MI Replicate 2 Col1a1 GFP+ Cardiac Fib…
- GSM8263037 Col1a1 GFP+ Cardiac Fibroblasts 1 days after MI Replicate 3 Col1a1 GFP+ Cardiac Fib…
- GSM8263038 Col1a1 GFP+ Cardiac Fibroblasts 2 days after MI Replicate 1 Col1a1 GFP+ Cardiac Fib…
- GSM8263039 Col1a1 GFP+ Cardiac Fibroblasts 2 days after MI Replicate 2 Col1a1 GFP+ Cardiac Fib…
- GSM8263040 Col1a1 GFP+ Cardiac Fibroblasts 2 days after MI Replicate 3 Col1a1 GFP+ Cardiac Fib…
- GSM8263041 Col1a1 GFP+ Cardiac Fibroblasts 4 days after MI Replicate 1 Col1a1 GFP+ Cardiac Fib…
- GSM8263042 Col1a1 GFP+ Cardiac Fibroblasts 4 days after MI Replicate 2 Col1a1 GFP+ Cardiac Fib…
- GSM8263043 Col1a1 GFP+ Cardiac Fibroblasts 4 days after MI Replicate 3 Col1a1 GFP+ Cardiac Fib…
- GSM8263044 Col1a1 GFP+ Cardiac Fibroblasts 5 days after MI Replicate 3
- GSM8263045 Col1a1 GFP+ Cardiac Fibroblasts 6 days after MI Replicate 1 Col1a1 GFP+ Cardiac Fib…
- GSM8263046 Col1a1 GFP+ Cardiac Fibroblasts 6 days after MI Replicate 2 Col1a1 GFP+ Cardiac Fib…
- GSM8263047 Col1a1 GFP+ Cardiac Fibroblasts 6 days after MI Replicate 3 Col1a1 GFP+ Cardiac Fib…
- GSE306012 Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction 28 samples shares fibroblasts, myocardial, infarction
- GSE307268 Experimentally induced myocardial infarction in mice - RNA Sequencing of sham left ventricular tissue and infarct zones 17 samples shares ventricular, myocardial, infarction
- GSE277680 Mitochondrial Ferritin Inhibition Aggravates Pacing-induced Ventricular Arrhythmias after Myocardial Infarction by Promoting Cardiomyocytes Ferroptosis 12 samples shares ventricular, myocardial, infarction
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares ventricular, infarction
- GSE261643 Hippo deficient cardiac fibroblasts promote atrial remodeling 24 samples shares fibroblasts, remodeling
- GSE187002 CXCL9 links skin inflammation and fibrosis via CXCR3-dependent upregulation of collagen 1a1 in fibroblasts 24 samples shares fibroblasts, collagen
- GSE284092 Myocardial Fibroblasts are a Primary Source High Molecular Weight Hyaluronan Production in the Failing Heart 20 samples shares fibroblasts, myocardial
- GSE266899 The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen hydroxyprolination and favoring immune infiltration. 18 samples shares fibroblasts, collagen
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.