GEO series
Bulk RNA sequence and bulk ATAC sequence of treated murine CD8+ T cells
GSE190603
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
25 samples
2024/06/28
GPL21103
Summary
We identify that GSH maintains the function of CD8+ T cell and GSH metabolism is interacting with A2AR signaling pathway to reshape the metabolism and anti-function in CD8+ T cell. We found A2AR signaling blockade leads to the upregulation of GSH metabolism related genes and loss of the genes abolishes the benefits from A2AR antagonist on CD8+ T cells. Considering to the essential role of GSH metabolism in ferroptosis, we combined the potent ferroptosis inhibitor liproxstatin-1 (Lip-1) and A2AR antagonist (SCH58261) to treat CD8+ T cells. Notably, our combination therapy significantly promotes the anti-tumor immunity of CD8+ T cells with delayed tumor growth in tumor bearing mice.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE222656 RNA-seq and Cut & Tag analyses of mouse 2-cell embryos in which lamin B1 dissociation from the nuclear envelope is inhibited 40 samples
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis 50 samples
- GSE297837 ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment. 126 samples
- GSE333807 Single-nucleus multiomic profiling of hippocampus and frontal cortex in a C9orf72 knockout mouse model 52 samples
- GSE294389 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis 131 samples
- GSE296994 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation 174 samples
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples
- GSE243165 Signal-responsive transcription factors cooperate to establish alveolar macrophage identity 42 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.