GEO series
Single-nucleus multiomic profiling of hippocampus and frontal cortex in a C9orf72 knockout mouse model
GSE333807
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
52 samples
2026/06/03
GPL24247GPL34290
Summary
This project contains single-nucleus multiomic sequencing data generated from hippocampal and frontal cortex tissue collected from wild-type, heterozygous, and C9orf72 knockout mice. Single-nucleus transcriptomic and chromatin accessibility profiles were generated using the 10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression platform to simultaneously measure gene expression and chromatin accessibility within individual nuclei. The dataset was generated to investigate cell type-specific molecular and regulatory alterations associated with reduced or absent C9orf72 function in brain regions relevant to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Libraries were prepared for paired gene expression and chromatin accessibility assays and sequenced on the Illumina NovaSeq 6000 platform.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE222656 RNA-seq and Cut & Tag analyses of mouse 2-cell embryos in which lamin B1 dissociation from the nuclear envelope is inhibited 40 samples
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis 50 samples
- GSE297837 ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment. 126 samples
- GSE294389 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis 131 samples
- GSE296994 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation 174 samples
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples
- GSE243165 Signal-responsive transcription factors cooperate to establish alveolar macrophage identity 42 samples
- GSE334540 Single nucleus multiome (RNAseq and ATACseq) of male and female mouse pituitary 32 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.