GEO series
Transcriptomic sterol response in the HepG2 human hepatoma cell line
GSE190736
Homo sapiens
Expression profiling by high throughput sequencing
69 samples
2024/12/10
GPL11154
Summary
Statins are cholesterol lowering drugs that inhibit cholesterol synthesis and reduce intracellular sterol levels, stimulating a transcriptional response. We sought to identify genes that were statin responsive in the HepG2 human hepatoma cell line and determine which of those genes were sterol responsive using sterol addback conditions. Though the vast majority of statin responsive genes are sterol responsive, we identified a subset of statin responsive genes whose gene expression changes are not reversed upon sterol addback.
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