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Single cell RNA-seq data of colonic and small intestinal epithelium from Ecsit fl/fl and Ecsit cKO mice

GSE193360 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/31 Platform GPL24247
Summary
To investigate the specific role of Ecsit in intestinal homeostasis, we generated Ecsit floxed/Vil1-Cre-ERT2 mouse model, and injected tamoxifen (3mg) intraperitoneally for 5 consecutive days to achieve conditional deletion of Ecsit in the intestinal epithelium at a specific time. These Ecsit fl/fl Vil1-Cre-ERT2 mice (Ecsit cKO) and Control mice (Ecsit fl/fl) mice were euthanized 12 days after the last injection for single cell RNA-seq on small intestinal and colonic epithelium.
Published in
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein
Jiang Y, Ma C, Hu Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 · PMID 37409430 · doi:10.1002/advs.202205180
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Direct links to NCBI, no account and no request form: the whole study as GSE193360_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA795962 and SRA study SRP354239. Searching any of these in the dataset finder brings you back here.

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