GEO series

Dynamic responses of primary human bronchial epithelial cells to influenza virus, viral RNA and interferon-beta

GSE19392 Homo sapiens Expression profiling by array 169 samples Submitted 2010/03/30 Platform GPL3921

Summary

We defined the major transcriptional responses in primary human bronchial epithelial cells (HBECs) after either infection with influenza or treatment with relevant ligands. We used four different strategies, each highlighting distinct aspects of the response. (1) cells were infected with the wild-type PR8 influenza virus that can mount a complete replicative cycle. (2) cells were transfected with viral RNA (‘vRNA’) isolated from influenza particles. This does not result in the production of viral proteins or particles and identifies the effect of RNA-sensing pathways (e.g., RIG-I.). (3) Cells were treated with interferon beta (IFNb), to distinguish the portion of the response which is mediated through Type I IFNs. (4) Cells were infected with a PR8 virus lacking the NS1 gene (‘DNS1’). The NS1 protein normally inhibits vRNA- or IFNb-induced pathways, and its deletion can reveal an expanded response to infection.

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Direct links to NCBI, no account and no request form: the whole study as GSE19392_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 169 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA121751. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 20064372) ↗

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