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LKB1 regulates adipose tissue ILC2 function through regulating mitochonrial

GSE196196 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/09/17 Platform GPL23479
Summary
Our study represents LKB1 defects lead to the loss and dysfunction of adipose tissue ILC2s.And we found that LKB1 regulate ILC2s homeostasis and cytokines function in a cell-intrinsic manner.In high-diet-fed mice,LKB1 in ILC2s protects against metabolic disturbances and fat fibrosis.LKB1 deficient in ILC2 impaired the oxidative phosphorylation and led to mitochondria loss though more mitophagy.
Published in
Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
Sun J, Zhang Y, Zhang Q et al. · Immunity 2024 · PMID 38772366 · doi:10.1016/j.immuni.2024.04.024
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Also filed as BioProject PRJNA803884 and SRA study SRP358563. Searching any of these in the dataset finder brings you back here.

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