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Physiological transcriptional profiling of murine osteocytes from calvaria and long bones

GSE199176 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/22 Platform GPL18480
Summary
Different bones of the skeleton originate from three distinct embryonic lineages. Osteoblasts derived from bones of different embryonic origin displayed cell intrinsic difference. Osteocytes are terminally differentiated osteoblasts which displays a unique genetic makeup and a distinct morphology. It is not know if osteocytes display a cell intrinsic differences depeding on their origin. To understand the difference in the gene expression profiles of osteocytes of three different embryonic origins we examined osteocytes from three different bones neural crest origin-frontal bone, paraxial mesoderm origin-parietal bone, and lateral plate mesoderm- femur bone.
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Direct links to NCBI, no account and no request form: the whole study as GSE199176_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA818696 and SRA study SRP365323. Searching any of these in the dataset finder brings you back here.

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