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A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML

GSE199756 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/01 Platform GPL21626
Summary
In the murine HoxA9/Meis1 (H9M) AML model leukemic stem cell (LSC) potential lies in three different heterogeneous immunophenotypes including Lin-cKit+ progenitor cells (Lin-), Gr1+CD11b+cKit+ myeloid cells and lymphoid cells (Lym+). We performed Bulk-RNA sequencing to reveal differences in the transcriptional program between Lin- and Lym+ cells. Therefore, Lin- and Lym+ cells of secondary AML mouse bone marrow was isolated and sequenced. We could identify potential lymphoid master regulators that correlated with lymphoid cell development and presumably aggressive disease.
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Direct links to NCBI, no account and no request form: the whole study as GSE199756_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA821455 and SRA study SRP366660. Searching any of these in the dataset finder brings you back here.

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