GEO series
Effects of KRAS (G13C) expression on transcriptome profiles assessed in HPCs differentiated from patient-derived iPS cells
GSE200600
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/04/01
GPL24676GPL11154
Summary
How a single oncogenic RAS impacts non-transformed hematopoietic progenitor cells (HPCs) remains largely unknown. We therefore investigated how a monoallelic KRAS mutation (G13C) affected HPCs utilizing induced pluripotent stem cells (iPSCs) derived from two unrelated patients with RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD).
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Paper (PMID 38627844) ↗
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