Effects of KRAS (G13C) expression on transcriptome profiles assessed in HPCs differentiated from patient-derived iPS cells
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cellsStem cell research & therapy · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE200600_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA825504 and SRA study SRP369501. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6038480 Pt1 iPSC-HPCs, WTcontrol, unstimulated
- GSM6038481 Pt1 iPSC-HPCs, WTcontrol, stimulated_SF
- GSM6038482 Pt1 iPSC-HPCs, WTcontrol, stimulated_STF3
- GSM6038483 Pt1 iPSC-HPCs, KRASG13C, unstimulated
- GSM6038484 Pt1 iPSC-HPCs, KRASG13C, stimulated_SF
- GSM6038485 Pt1 iPSC-HPCs, KRASG13C, stimulated_STF3
- GSM6038486 Pt2 iPSC-HPCs, WTcontrol, unstimulated
- GSM6038487 Pt2 iPSC-HPCs, WTcontrol, stimulated_SF
- GSM6038488 Pt2 iPSC-HPCs, WTcontrol, stimulated_STF3
- GSM6038489 Pt2 iPSC-HPCs, KRASG13C, unstimulated
- GSM6038490 Pt2 iPSC-HPCs, KRASG13C, stimulated_SF
- GSM6038491 Pt2 iPSC-HPCs, KRASG13C, stimulated_STF3
- GSE312023 Effect of BMP2, BMP3, BMP4, IL6, LIF, and OSM on the gene expression profiles of two patient-derived glioblastoma neurosphere lines. 27 samples shares patient-derived, profiles
- GSE225061 Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response 217 samples shares kras
- GSE230860 Overlapping and Distinct Transcriptional Functions of an Extended Repertoire of KRAS Mutations 114 samples shares kras
- GSE295683 RNA-seq Analysis of KRAS Mutant HPNE Pancreatic Ductal Epithelial Cells 66 samples shares kras
- GSE328821 U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations [RNA-Seq] 53 samples shares kras
- GSE273492 Selective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [RNA-Seq] 36 samples shares kras
- GSE262660 SCD1-dependant activation of GSK3β-NRF2-SLC7A11 pathway regulates lipid metabolism and suppresses ferroptosis in KRAS/STK11/KEAP1 co-mutant lung adenocarcinoma 36 samples shares kras
- GSE225060 Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response (RNA-Seq). 33 samples shares kras
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.