m6A RNA modification cooperates with alternative polyadenylation to control T cell homeostasis via mTOR signaling
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- m(6)A RNA modification guides alternative polyadenylation to maintain T cell quiescenceScience advances · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE202164_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA834821 and SRA study SRP373471. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6102458 naive CD4+ T cells, Mettl3 WT1, 0H
- GSM6102459 naive CD4+ T cells, Mettl3 WT2, 0H
- GSM6102460 naive CD4+ T cells, Mettl3 WT3, 0H
- GSM6102461 naive CD4+ T cells, Mettl3 WT1, 48H
- GSM6102462 naive CD4+ T cells, Mettl3 WT2, 48H
- GSM6102463 naive CD4+ T cells, Mettl3 WT3, 48H
- GSM6102464 naive CD4+ T cells, Mettl3 KO1, 0H
- GSM6102465 naive CD4+ T cells, Mettl3 KO3, 0H
- GSM6102466 naive CD4+ T cells, Nudt21 WT1, 0H
- GSM6102467 naive CD4+ T cells, Nudt21 WT2, 0H
- GSM6102468 naive CD4+ T cells, Nudt21 KO1, 0H
- GSM6102469 naive CD4+ T cells, Nudt21 KO2, 0H
- GSE242179 Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification 40 samples shares modification, alternative
- GSE276270 NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis 36 samples shares homeostasis, control
- GSE326488 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [RNA-Seq mouse] 14 samples shares homeostasis, control
- GSE326641 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [scRNA-seq] 8 samples shares homeostasis, control
- GSE333480 METTL3-mediated m6A modification controls Tcra recombination center formation and thymic T cell development 98 samples shares modification, control
- GSE255571 Chromatin remodeler CHD7 regulates neurogenic gene expression via controlling chromatin accessibility and modifications of histone marks H3K27me3 and H3K4me3 [Mouse CUT&Tag] 10 samples shares modification, control
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares homeostasis
- GSE326538 Aqueous Artemisia argyi extract mitigates acute lung injury by coordinating gut microbiota, metabolic homeostasis, and pulmonary inflammatory signaling 24 samples shares homeostasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.