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Altered gene expression is associated with age-dependent memory impairment

GSE20270 Mus musculus Expression profiling by array 24 samples Submitted 2010/04/19 Platform GPL4134
Summary
The mechanisms underlying age-associated memory impairment are not well understood. We have shown that the onset of memory disturbances in the aging brain is associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation. To analyze if deregulated H4K12 acetylation impacts on learning-induced gene-expression required for memory consolidation we performed a high-density oligonucleotide microarray to compare the entire hippocampal gene-expression profile of 3 and 16-month-old mice during memory consolidation.
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Also filed as BioProject PRJNA124135. Searching any of these in the dataset finder brings you back here.

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