COMPASS complex inhibition targets the metastasis initiating cell in undifferentiated pleomorphic sarcoma
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 20 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPSiScience · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE208367_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA859685 and SRA study SRP386859. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 26 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6341908 Control-Metastatic cell [RNA_seq_1_AAV2]
- GSM6341909 Control-Metastatic cell [RNA_seq_2_AAV2]
- GSM6341910 Control-Metastatic cell [RNA_seq_3_AAV2]
- GSM6341911 Setd1a KO-Metastatic cell [RNA_seq_1_1350]
- GSM6341912 Setd1a KO-Metastatic cell [RNA_seq_2_1350]
- GSM6341913 Setd1a KO-Metastatic cell [RNA_seq_3_1350]
- GSM6341914 Metastatic mouse UPS cell, H3K4Me3, rep1
- GSM6341915 Metastatic mouse UPS cell, H3K4Me3, rep2
- GSM6341916 Metastatic mouse UPS cell lacking Setd1a, H3K4Me3, rep1
- GSM6341917 Metastatic mouse UPS cell lacking Setd1a, H3K4Me3, rep2
- GSM6341918 Metastatic mouse UPS cell, IgG, rep1
- GSM6341921 Metastatic mouse UPS cell, IgG, rep2
- GSM6341922 Metastatic mouse UPS cell, IgG, rep3
- GSM6341923 Metastatic mouse UPS cell lacking Setd1a, IgG, rep1
- GSM6341924 Metastatic mouse UPS cell lacking Setd1a, IgG, rep2
- GSM6341925 Metastatic mouse UPS cell lacking Setd1a, IgG, rep3
- GSM6341926 277RFP
- GSM6341927 277YFP
- GSM6341928 277GFP
- GSM6341929 732CFP
- GSM6341930 732YFP
- GSM6341931 732RFP
- GSM6341932 324YFP
- GSM6341933 324RFP
- GSM6341934 324C+R
- GSM6341935 324CFP
- GSE253444 Combining TIGIT blockade with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity 55 samples shares inhibition, metastasis
- GSE309033 Combined BET Bromodomain and DNMT Inhibition Targets Lineage Plasticity in Prostate Cancer [BETi_DNMTi_mouse_RNAseq] 51 samples shares inhibition, targets
- GSE272923 Complex I Inhibition combined with TLR Activation in the Breast Tumor Microenvironment Educates Cytotoxic Neutrophils. 35 samples shares inhibition, complex
- GSE241629 Inhibition of Notch4 with Novel Neutralizing Antibodies Reduces Tumor Growth in Multiple Tumor Types and Targets Endothelium and Tumor Associated Macrophages in a Mouse Breast Cancer Model [RiboTag RNA-seq] 20 samples shares inhibition, targets
- GSE334363 PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway 18 samples shares inhibition, metastasis
- GSE309163 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [ChIP-Seq] 16 samples shares inhibition, targets
- GSE309162 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [RNA-Seq] 12 samples shares inhibition, targets
- GSE299379 KAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [RNA-Seq] 35 samples shares compass
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.