RNA sequencing of slow-and fast-cycling epidermal stem cells vs hair follicle stem cells in murine back skin, tail skin vs oral epithelium

This study was performed to compare transcriptomic changes in the heterogeneous mouse skin epidermal stem cells and mouse oral epithelial stem cells during homeostasis at young age. Slow-cycling stem cells (label retaining cells, LRCs), fast-cycling stem cells (non-label retaining cells, nLRCs) express unique gene signatures in both skin and oral tissues and have independent stem cell identities. Our data indicates that there are similarities and differences in gene expression patterns between LRC and non-LRC populations in different epithelial tissues, suggesting stem cell autonomous heterogeneity and environmental differences.