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Effect of Notch over-expression on murine liposarcoma cells

GSE210457 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/01 Platform GPL28330
Summary
This RNA-seq analysis compares gene expression of a murine liposarcoma cell line with or without over-expression of Notch1 intracellular domain (NICD). The NICD overexpressing cell line (mLPS1) was derived from a corresponding mouse model that specifically express NICD in adipocytes, which leads to development of tumor resembling human dedifferentiated liposarcoma (LPS). From the mLPS1 cell line, a new cell line was derived after CRISPR-Cas9 mediated removal of the NICD expressing cassette (mLPS1-dNICD). Gene expression profiling analysis was performed on the mLPS1 and mLPS1-dNICD cells collected at three different passages.
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Direct links to NCBI, no account and no request form: the whole study as GSE210457_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA865747 and SRA study SRP389715. Searching any of these in the dataset finder brings you back here.

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