Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 × LA_fed vs 6 × LA_fasted vs 6 × LT_fed vs 6 × LT_fastedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout MiceArteriosclerosis, thrombosis, and vascular biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE210460_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA865746 and SRA study SRP389717. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6430668 LA_fed_1 LA_fed
- GSM6430669 LA_fed_2 LA_fed
- GSM6430670 LA_fed_3 LA_fed
- GSM6430671 LA_fed_4 LA_fed
- GSM6430672 LA_fed_5 LA_fed
- GSM6430673 LA_fed_6 LA_fed
- GSM6430674 LA_fasted_1 LA_fasted
- GSM6430675 LA_fasted_2 LA_fasted
- GSM6430676 LA_fasted_3 LA_fasted
- GSM6430677 LA_fasted_4 LA_fasted
- GSM6430678 LA_fasted_5 LA_fasted
- GSM6430679 LA_fasted_6 LA_fasted
- GSM6430680 LT_fed_1 LT_fed
- GSM6430681 LT_fed_2 LT_fed
- GSM6430682 LT_fed_3 LT_fed
- GSM6430683 LT_fed_4 LT_fed
- GSM6430684 LT_fed_5 LT_fed
- GSM6430685 LT_fed_6 LT_fed
- GSM6430686 LT_fasted_1 LT_fasted
- GSM6430687 LT_fasted_2 LT_fasted
- GSM6430688 LT_fasted_3 LT_fasted
- GSM6430689 LT_fasted_4 LT_fasted
- GSM6430690 LT_fasted_5 LT_fasted
- GSM6430691 LT_fasted_6 LT_fasted
- GSE255321 Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice 24 samples shares ldlr, atherosclerosis
- GSE267751 Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signaling. 71 samples shares time-restricted, feeding
- GSE292193 RNA-Seq Reveals Enhanced Inflammation and Fibrosis in Alcohol-Induced Liver Injury of Apoe Knockout Mice 18 samples shares knockout, apoe
- GSE272153 Deletion of the mouse homolog of human FHR1 (FHRE) protects ApoE-/- mice from atherosclerosis 12 samples shares atherosclerosis, apoe
- GSE294054 Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice 39 samples shares ldlr
- GSE297526 ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR abundance on hepatic surface 15 samples shares ldlr
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares knockout
- GSE274144 ATAC-seq of VLDLR+ vs VLDLR- HSCs after acute anemia induction 14 samples shares ldlr
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.