Deletion of the mouse homolog of human FHR1 (FHRE) protects ApoE-/- mice from atherosclerosis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × WT mouse vs 3 × APOE KO vs 3 × FHRE KO vs 3 × APOE & FHRE 2xKOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Deletion of the Mouse Homolog of Human FHR1 (muFHR1) Alleviates Atherosclerosis in ApoE-/- miceInternational journal of medical sciences · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272153_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1135219 and SRA study SRP519596. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8394724 WT mouse Rep1 WT mouse
- GSM8394725 WT mouse Rep2 WT mouse
- GSM8394726 WT mouse Rep3 WT mouse
- GSM8394727 APOE KO Rep1 APOE KO
- GSM8394728 APOE KO Rep2 APOE KO
- GSM8394729 APOE KO Rep3 APOE KO
- GSM8394730 FHRE KO Rep1 FHRE KO
- GSM8394731 FHRE KO Rep2 FHRE KO
- GSM8394732 FHRE KO Rep3 FHRE KO
- GSM8394733 APOE & FHRE 2xKO Rep1 APOE & FHRE 2xKO
- GSM8394734 APOE & FHRE 2xKO Rep2 APOE & FHRE 2xKO
- GSM8394735 APOE & FHRE 2xKO Rep3 APOE & FHRE 2xKO
- GSE338380 Hepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housing 48 samples shares deletion, protects
- GSE210460 Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice 24 samples shares atherosclerosis, apoe
- GSE271317 Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway 12 samples shares deletion, protects
- GSE328896 Patch-seq analysis of dorsal striatum cholinergic interneurons in a mouse model of 22q11 deletion syndrome 125 samples shares deletion
- GSE223376 TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy 72 samples shares deletion
- GSE254396 Single-cell and bulk RNA sequencing of mouse atherosclerosis disease stage course [TRAP-seq] 71 samples shares atherosclerosis
- GSE220322 Gene expression in pre-cystic mouse kidneys after Pkd2 deletion. 48 samples shares deletion
- GSE307127 Immune Receptor Lag3 Deletion Alleviates Neurodegeneration Phenotypes in a Mouse Model of Alzheimer’s Disease 36 samples shares deletion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.