Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Nasopharyngeal carcinomaThis series is part of our curated briefing on it.
- Samples
- 10 samples: 8 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE214026_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA883647 and SRA study SRP399241. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 10 sample titles: 8 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6598038 5-8F P input
- GSM6598039 5-8F P H3K4me3
- GSM6598040 5-8F P H3K27Ac
- GSM6598041 5-8F R input
- GSM6598042 5-8F R H3K4me3
- GSM6598043 5-8F R H3K27Ac
- GSM6598051 5-8F P1
- GSM6598052 5-8F P2
- GSM6598053 5-8F R1
- GSM6598054 5-8F R2
- GSE214023 Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma [ChIP-Seq] 6 samples same disease briefing · shares chemoresistance, nasopharyngeal, remodeling, activates, enhancer, advanced, confer, notch
- GSE214025 Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma [RNA-Seq] 4 samples same disease briefing · shares chemoresistance, nasopharyngeal, remodeling, activates, enhancer, advanced, confer, notch
- GSE243953 KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma 9 samples same disease briefing · shares nasopharyngeal, remodeling
- GSE225251 Enhancer infestation drives tumorigenic activation of inactive compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma 26 samples same disease briefing · shares nasopharyngeal, enhancer
- GSE169589 N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-Catenin pathway in nasopharyngeal carcinoma 20 samples same disease briefing · shares chemoresistance, nasopharyngeal
- GSE186485 18S rRNA N6-methyladenosine (m6A) modification promotes tumorigenesis and chemoresistance via gain-of-function mutant p53 in nasopharyngeal carcinoma 16 samples same disease briefing · shares chemoresistance, nasopharyngeal
- GSE263067 DDX5 super-enhancer promote vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription 2 samples same disease briefing · shares nasopharyngeal, enhancer
- GSE102349 Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-based Subtypes 113 samples same disease briefing · shares nasopharyngeal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.