GEO series
Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop [ATACseq_ChIPseq_RNAseq]
GSE214190
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
35 samples
2025/02/20
GPL21103
Summary
Whether oxidative stress (OxS) acts mutationally or epigenetically to increase cancer risk is unknown. Pancreatic ductal carcinoma (PDAC) evolves from benign, low-grade PanIN (pancreatic intraepithelial neoplasia) lesions that frequently express oncogenic KRAS. Postulating that known risk factors convert benign PanIN to malignant progenitors via OxS and epigenetic mechanisms, we established a novel system to test this hypothesis. Transient incubation of organoids, derived from pancreata with KrasG12D-induced low-grade PanIN, with H2O2 triggered irreversible malignant conversion mediated by an epigenetic network composed of NRF2, its direct transcriptional target EZH2, and EZH2-interacting transcription factors. Pharmacological or genetic activation of this network, maintained by a single NRF2 site in the EZH2 promoter, also triggered rapid malignant conversion and upregulation of malignancy-supportive metabolic genes that remained elevated in established PDAC.
Download
NCBI GEO page ↗
Paper (PMID 40588523) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE222656 RNA-seq and Cut & Tag analyses of mouse 2-cell embryos in which lamin B1 dissociation from the nuclear envelope is inhibited 40 samples
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis 50 samples
- GSE297837 ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment. 126 samples
- GSE333807 Single-nucleus multiomic profiling of hippocampus and frontal cortex in a C9orf72 knockout mouse model 52 samples
- GSE294389 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis 131 samples
- GSE296994 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation 174 samples
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples
- GSE243165 Signal-responsive transcription factors cooperate to establish alveolar macrophage identity 42 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.