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Investigation of anti-cancer effects of 6-shogaol on glioma through analysis of transcriptome and experimental verification

GSE214898 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/01 Platform GPL16791
Summary
Glioma is one of the most fatal and complex cancer types. Patients have poor prognosis due to aggressive disease progression or tumor recurrence, resulting in poor survival. Ginger (Zingiber officinale Roscoe) is extensively regarded as a traditional Chinese herbal medicine or condiment in cooking in Asia. 6-shogaol, the most abundant ingredient in ginger, has antiviral, anti-inflammatory, and anticancer properties. However, there are no data on 6-shogaol against glioma, and its potential mechanism has not been thoroughly elucidated. Our study demonstrated that 6-shogaol significantly inhibited glioma cell growth, migration and invasion, and induced cell apoptosis in vitro and in vivo. Transcriptomic analysis and western blot data indicated that 6-shogaol significantly upregulated the p38-MAPK pathway, which plays a key factor in its powerful antitumor effect. These findings demonstrated that 6-shogaol has a strong anti-tumor activity in glioma, which through regulating the p38-MAPK signaling pathway.
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Direct links to NCBI, no account and no request form: the whole study as GSE214898_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA887687 and SRA study SRP401278. Searching any of these in the dataset finder brings you back here.

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