← BioTransfer GEO Dataset Finder
GEO series

A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response

GSE21761 Mus musculus Expression profiling by array 43 samples Submitted 2010/08/09 Platform GPL1261
Summary
Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association with hnRNP-K. This interaction is required for proper genomic localization of hnRNP-K at repressed genes and regulation of p53 mediated apoptosis. We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulating their localization to sets of previously active genes.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE21761_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 43 samples.

Also filed as BioProject PRJNA127275. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 43 more — browse all 43 samples with per-sample file links →

Similar datasets

Search all mouse microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.