Nucleus Accumbens MEF2C Mediates the Maintenance of Peripheral Nerve Injury-induced Physiological and Behavioral Maladaptations
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 × Sham-Gfp-NAc, vs 6 × Sham-Mef2c-NAc, vs 6 × SNI-Gfp-NAc, vs 6 × SNI-Mef2c-NAc,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptationsPain · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269326_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1121227 and SRA study SRP512401. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8313148 Sham-Gfp-NAc, replicate1 Sham-Gfp-NAc,
- GSM8313149 Sham-Gfp-NAc, replicate2 Sham-Gfp-NAc,
- GSM8313150 Sham-Gfp-NAc, replicate3 Sham-Gfp-NAc,
- GSM8313151 Sham-Gfp-NAc, replicate4 Sham-Gfp-NAc,
- GSM8313152 Sham-Gfp-NAc, replicate5 Sham-Gfp-NAc,
- GSM8313153 Sham-Gfp-NAc, replicate6 Sham-Gfp-NAc,
- GSM8313154 Sham-Mef2c-NAc, replicate1 Sham-Mef2c-NAc,
- GSM8313155 Sham-Mef2c-NAc, replicate2 Sham-Mef2c-NAc,
- GSM8313156 Sham-Mef2c-NAc, replicate3 Sham-Mef2c-NAc,
- GSM8313157 Sham-Mef2c-NAc, replicate4 Sham-Mef2c-NAc,
- GSM8313158 Sham-Mef2c-NAc, replicate5 Sham-Mef2c-NAc,
- GSM8313159 Sham-Mef2c-NAc, replicate6 Sham-Mef2c-NAc,
- GSM8313160 SNI-Gfp-NAc, replicate1 SNI-Gfp-NAc,
- GSM8313161 SNI-Gfp-NAc, replicate2 SNI-Gfp-NAc,
- GSM8313162 SNI-Gfp-NAc, replicate3 SNI-Gfp-NAc,
- GSM8313163 SNI-Gfp-NAc, replicate4 SNI-Gfp-NAc,
- GSM8313164 SNI-Gfp-NAc, replicate5 SNI-Gfp-NAc,
- GSM8313165 SNI-Gfp-NAc, replicate6 SNI-Gfp-NAc,
- GSM8313166 SNI-Mef2c-NAc, replicate1 SNI-Mef2c-NAc,
- GSM8313167 SNI-Mef2c-NAc, replicate2 SNI-Mef2c-NAc,
- GSM8313168 SNI-Mef2c-NAc, replicate3 SNI-Mef2c-NAc,
- GSM8313169 SNI-Mef2c-NAc, replicate4 SNI-Mef2c-NAc,
- GSM8313170 SNI-Mef2c-NAc, replicate5 SNI-Mef2c-NAc,
- GSM8313171 SNI-Mef2c-NAc, replicate6 SNI-Mef2c-NAc,
- GSE330744 Differential physiological, behavioral, and medial prefrontal cortex transcriptomic responses to chronic restraint stress between BALB/c and C57BL/6J mice 12 samples shares physiological, behavioral
- GSE306312 Peripheral nerve injury-induced remodeling of the tumor-associated macrophages promotes immune evasion in breast cancer 6 samples shares injury-induced, peripheral
- GSE287284 Spinal neuronal ferroptosis aggravates peripheral nerve injury-induced neuropathic pain via modulating competing endogenous RNA axis - RNA-Seq 6 samples shares injury-induced, peripheral
- GSE254342 Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments 2 samples shares physiological, behavioral
- GSE300140 Engineering effector domains of MEF2C and GATA4 enhances cardiac reprogramming 15 samples shares mef2c
- GSE280543 Heart tube morphogenesis is regulated by segment-specific gene regulatory networks controlled by MEF2C [snRNA-Seq] 12 samples shares mef2c
- GSE253629 Pre- and postsynaptic MEF2C promote experience-dependent, input-specific development of Layer 4 to Layer 2/3 excitatory synapses 12 samples shares mef2c
- GSE243331 PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle 6 samples shares mef2c
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.