Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 11 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 4 × WT vs 3 × KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE218984_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA906509 and SRA study SRP410429. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 7 samples.
How we read this: 2 replicated groups read from 11 sample titles; they account for 7 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6761405 WT-H4h Input
- GSM6761406 WT-H4h IP
- GSM6761407 KO-H4h Input
- GSM6761408 KO-H4h IP
- GSM6761448 WT1 WT
- GSM6761449 WT2 WT
- GSM6761450 WT3 WT
- GSM6761451 WT4 WT
- GSM6761452 KO1 KO
- GSM6761453 KO2 KO
- GSM6761454 KO3 KO
- GSE304488 EET Reduction Contributes to Granulosa Cell Senescence And Endometriosis-Associated Infertility Via the PI3K/AKT/mTOR Signaling Pathway 16 samples shares endometriosis-associated, contributes, infertility, granulosa
- GSE214191 Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop 63 samples shares ezh2
- GSE262920 EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice 47 samples shares ezh2
- GSE214190 Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop [ATACseq_ChIPseq_RNAseq] 35 samples shares ezh2
- GSE254318 EZH2 loss promotes gastric squamous cell carcinoma 32 samples shares ezh2
- GSE250575 CCN6/WISP3 suppresses metaplastic breast carcinoma by antagonizing a WNT/b-catenin/EZH2 cascade 28 samples shares ezh2
- GSE254328 Epigenetic regulation of chromosomal instability by EZH2 methyltransferase 26 samples shares ezh2
- GSE233537 Modulation of activated T cells by transient EZH2 inhibition 17 samples shares ezh2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.