Epigenetic regulation of chromosomal instability by EZH2 methyltransferase
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic Regulation of Chromosomal Instability by EZH2 MethyltransferaseCancer discovery · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254328_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1069747 and SRA study SRP486154. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 8 replicated groups read from 26 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8037745 H3K27me3_GFPpos_Untreated_Day7
- GSM8037746 H3K27me3_GFPpos_Untreated_Day7 replicate 2 H3K27me3_GFPpos_Untreat…
- GSM8037747 H3K27me3_GFPpos_Untreated_Day7 replicate 3 H3K27me3_GFPpos_Untreat…
- GSM8037748 H3K27me3_GFPpos_EPZ_Day7
- GSM8037749 H3K27me3_GFPpos_EPZ_Day7 replicate 2 H3K27me3_GFPpos_EPZ_Day7
- GSM8037750 H3K27me3_GFPpos_EPZ_Day7 replicate 3 H3K27me3_GFPpos_EPZ_Day7
- GSM8037751 H3K27me3_GFPpos_EPZ_Day7 replicate 4 H3K27me3_GFPpos_EPZ_Day7
- GSM8037752 H3K27me3_GFPneg_Untreated_Day7
- GSM8037753 H3K27me3_GFPneg_Untreated_Day7 replicate 2 H3K27me3_GFPneg_Untreat…
- GSM8037754 H3K27me3_GFPneg_Untreated_Day7 replicate 3 H3K27me3_GFPneg_Untreat…
- GSM8037755 H3K27me3_GFPneg_EPZ_Day7
- GSM8037756 H3K27me3_GFPneg_EPZ_Day7 replicate 2 H3K27me3_GFPneg_EPZ_Day7
- GSM8037757 H3K27me3_GFPneg_EPZ_Day7 replicate 3 H3K27me3_GFPneg_EPZ_Day7
- GSM8037758 H3K27me3_GFPneg_EPZ_Day7 replicate 4 H3K27me3_GFPneg_EPZ_Day7
- GSM8037759 D7-GFP-_DMSO D7-GFP-_DMSO
- GSM8037760 D7-GFP-_DMSO replicate 2 D7-GFP-_DMSO
- GSM8037761 D7-GFP-_DMSO replicate 3 D7-GFP-_DMSO
- GSM8037762 D7-GFP-_EPZ D7-GFP-_EPZ
- GSM8037763 D7-GFP-_EPZ replicate 2 D7-GFP-_EPZ
- GSM8037764 D7-GFP-_EPZ replicate 3 D7-GFP-_EPZ
- GSM8037765 D7-GFP_plus_DMSO D7-GFP_plus_DMSO
- GSM8037766 D7-GFP_plus_DMSO replicate 2 D7-GFP_plus_DMSO
- GSM8037767 D7-GFP_plus_DMSO replicate 3 D7-GFP_plus_DMSO
- GSM8037768 D7-GFP_plus_EPZ D7-GFP_plus_EPZ
- GSM8037769 D7-GFP_plus_EPZ replicate 2 D7-GFP_plus_EPZ
- GSM8037770 D7-GFP_plus_EPZ replicate 3 D7-GFP_plus_EPZ
- GSE254324 Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [CUT&RUN] 14 samples shares ezh2, methyltransferase, chromosomal, instability, epigenetic
- GSE254325 Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [RNA-seq] 12 samples shares ezh2, methyltransferase, chromosomal, instability, epigenetic
- GSE304090 Pharmacological inhibition of the epigenetic enzyme EZH2 attenuates cardiac dysfunction and mitigates lipid metabolism perturbations in a murine model of myocardial infarction 15 samples shares ezh2, epigenetic
- GSE298836 Loss of Histone Methyltransferase Ezh2 Exacerbates Polarization of Macrophages toward M2-Like Phenotypes by Hepatocellular Carcinoma [RNA-Seq] 14 samples shares ezh2, methyltransferase
- GSE45579 Sox4 is a master regulator of epithelial-mesenchymal transition (EMT) by controlling Ezh2 expression and epigenetic reprogramming 13 samples shares ezh2, epigenetic
- GSE277544 Inhibition of Histone Methyltransferase EZH2 for Immune-Interception of Colorectal Cancer in Lynch Syndrome 11 samples shares ezh2, methyltransferase
- GSE234033 Telomeric Chromosomal Instability Fosters Paracrine Mediated Cell Competition to Initiate Intestinal Cancer 10 samples shares chromosomal, instability
- GSE280300 Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [bulk RNA-seq] 24 samples shares chromosomal, instability
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.