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Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes

GSE220631 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/10 Platform GPL23479
Summary
Podocytes play a pivotal role in maintaining homeostasis of the glomerular filtration barrier. The underlying mechanism is unclear but podocyte loss represents a critical event that contributes to the development of diabetic kidney disease (DKD). Proteinase 3 (PR3) is a serine protease with selective high abundance in myeloid cells and pleiotropic effects on the regulation of innate immunity. Here, we demonstrate that PR3 abundance in the kidney was markedly increased, predominantly in podocytes, in a mouse model of DKD. Genetic ablation of PR3 significantly attenuated severe proteinuria, mesangial matrix expansion, and podocyte injury in diabetic mice. The present study aimed to investigate the role of PR3 in glomerular podocytes in DKD.
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Also filed as BioProject PRJNA910566 and SRA study SRP412274. Searching any of these in the dataset finder brings you back here.

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